Effects of Parkinson's disease on cognitive action control: Insights on impulsive response tendencies using an oculomotor Simon task
Identifieur interne : 000096 ( Main/Exploration ); précédent : 000095; suivant : 000097Effects of Parkinson's disease on cognitive action control: Insights on impulsive response tendencies using an oculomotor Simon task
Auteurs : Joan Duprez [France] ; Jean-François Houvenaghel [France] ; Soizic Argaud [France] ; Marc Vérin [France] ; Paul Sauleau [France]Source :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 2016-01.
Abstract
Objectives: Cognitive action control allows suppressing automatic activation and producing a controlled response when conflicts arise. This process is modulated by the basal ganglia and recent studies have shown that it was impaired in Parkinson's disease (PD). This study gives insights regarding the effect of PD on cognitive action and more precisely on impulsive responses. Methods: 40 patients with PD with no cognitive impairment and 40 healthy controls (HC) underwent an oculomotor Simon task in which they were required to make a leftward or rightward eye movement according to the color of a target and to ignore its location. The two dimensions of the stimuli created congruent (color and location activating the same response) and incongruent (color and location activating conflicting responses) trials. Results were analyzed using distributional analysis according to the activation-suppression model. Results: PD patients had a greater congruence effect on both reaction time and accuracy rate demonstrating a greater difficulty to resolve conflicts. Distributional analysis revealed that PD patients made more fast errors than HC. The rate of impulsive errors was further correlated to the Barrat Impulsiveness Scale (BIS) scores. When they responded slower, PD patients were also impaired compared to HC. Conclusions: Our results show that both the automatic and controlled routes involved in the cognitive action control are affected in PD. Furthermore, impulsive response tendencies in PD measured by a conflict task seems related to behavioral impulsivity. Therefore, conflict tasks could be used to further study impulsivity in PD and its ability to detect early troubles should be investigated
Url:
DOI: 10.1016/j.parkreldis.2015.10.515
Affiliations:
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Le document en format XML
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35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.ueb.eu/</ref></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>CHU Pontchaillou [Rennes]</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle><tutelle active="#struct-357205" type="direct"><org type="institution" xml:id="struct-357205" status="INCOMING"><orgName>Institut des Neurosciences Cliniques de Rennes (INCR)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-238036" status="VALID"><idno type="IdRef">184043662</idno><idno type="RNSR">201220290G</idno><orgName>Comportement et noyaux gris centraux [Rennes]</orgName><date type="start">2012</date><desc><address><addrLine>Université de Rennes 1 - Campus santé-Villejean - 2, Av Pr Léon Bernard - CS 3431735055 RENNES CEDEX</addrLine><country key="FR"></country></address><ref type="url">http://incr.fr/recherche/23-ea-4712-comportements-et-noyaux-gris-centraux</ref></desc><listRelation><relation name="EA4712" active="#struct-105160" type="direct"></relation><relation active="#struct-108091" type="direct"></relation><relation active="#struct-301327" type="direct"></relation><relation active="#struct-357205" type="direct"></relation></listRelation><tutelles><tutelle name="EA4712" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"><orgName>Université de Rennes 1</orgName><orgName type="acronym">UR1</orgName><desc><address><addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rennes1.fr/</ref></desc></org></tutelle><tutelle active="#struct-108091" type="direct"><org type="institution" xml:id="struct-108091" status="VALID"><orgName>Université européenne de Bretagne</orgName><orgName type="acronym">UEB</orgName><desc><address><addrLine>5 boulevard Laënnec - 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.ueb.eu/</ref></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>CHU Pontchaillou [Rennes]</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle><tutelle active="#struct-357205" type="direct"><org type="institution" xml:id="struct-357205" status="INCOMING"><orgName>Institut des Neurosciences Cliniques de Rennes (INCR)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.1016/j.parkreldis.2015.10.515</idno><series><title level="j">Parkinsonism and Related Disorders</title><idno type="ISSN">1353-8020</idno><imprint><date type="datePub">2016-01</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Cognitive action control allows suppressing automatic activation and producing a controlled response when conflicts arise. This process is modulated by the basal ganglia and recent studies have shown that it was impaired in Parkinson's disease (PD). This study gives insights regarding the effect of PD on cognitive action and more precisely on impulsive responses. Methods: 40 patients with PD with no cognitive impairment and 40 healthy controls (HC) underwent an oculomotor Simon task in which they were required to make a leftward or rightward eye movement according to the color of a target and to ignore its location. The two dimensions of the stimuli created congruent (color and location activating the same response) and incongruent (color and location activating conflicting responses) trials. Results were analyzed using distributional analysis according to the activation-suppression model. Results: PD patients had a greater congruence effect on both reaction time and accuracy rate demonstrating a greater difficulty to resolve conflicts. Distributional analysis revealed that PD patients made more fast errors than HC. The rate of impulsive errors was further correlated to the Barrat Impulsiveness Scale (BIS) scores. When they responded slower, PD patients were also impaired compared to HC. Conclusions: Our results show that both the automatic and controlled routes involved in the cognitive action control are affected in PD. Furthermore, impulsive response tendencies in PD measured by a conflict task seems related to behavioral impulsivity. Therefore, conflict tasks could be used to further study impulsivity in PD and its ability to detect early troubles should be investigated</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement><orgName><li>Université de Rennes 1</li><li>Université européenne de Bretagne</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Duprez, Joan" sort="Duprez, Joan" uniqKey="Duprez J" first="Joan" last="Duprez">Joan Duprez</name></region><name sortKey="Argaud, Soizic" sort="Argaud, Soizic" uniqKey="Argaud S" first="Soizic" last="Argaud">Soizic Argaud</name><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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